光电-李步洪
发布时间:2017-04-06 浏览次数: 4067

名:李步洪

称:教授

研究方向:生物医学光子学

学科专长:光学工程

联系电话0591-22867430                

E-MAILbhli@fjnu.edu.cn

通信地址:福州大学城金沙澳门登录网站光电与信息工程学院编:350117

个人概况:19738月生,福建连城人,光电与信息工程学院教授,博士生导师;现任金沙澳门登录网站常务副院长,入选教育部新世纪优秀人才支撑计划和福建省百千万工程领军人才。

教育经历:

 2000/9-2003/6  浙江大学,光学工程,博士

 1995/9-1998/6  金沙澳门登录网站,光学,硕士

 1991/9-1995/6  金沙澳门登录网站,物理教育,学士

科研与学术工作经历:

 2014/4-2014/8  洪堡大学物理研究所,高级研究学者

 2005/9-2007/9  多伦多大学医学院,访问学者

 2004/7-2006/7  西安交通大学生命科学学院,博士后研究员

学术兼职:

    中国光学学会激光医学专业委员会副主任委员

    中华医学会激光医学分会委员

    福建省医学会激光医学分会主任委员

    福建省光学学会副理事长兼秘书长

    Nano Biomedicine and Engineering副主编

    Journal of Innovative Optical Health Sciences编委

    Photonics & Lasers in Medicine编委

    《激光生物学报》常务编委

研究方向:主要从事医学光子技术及其临床应用研究

成果奖励

    李步洪,谢树森,陈荣,李晖,龚伟,激光成像式活检定位肿瘤的原理与技术研究,福建省科学技术二等奖,福建省人民政府,2009.

    李步洪,福建省优秀科技工编辑,福建科学技术协会,2016.

    谢树森,李晖,李步洪,陈荣,郑蔚,人体组织光学性质研究及其在激光医学中的应用,福建省科学技术一等奖,福建省人民政府,2002.

    李步洪,福建省青年科技奖,中共福建省委组织部、福建省人事厅、福建省科学技术厅、福建省科学技术协会,2006.

    李步洪,福建省运盛青年科技奖,福建省运盛青年基金会,2009.

科研项目:

    国家自然科学基金重点项目,61635014,增强血管靶向光动力效应的时空规律及调控研究,2017/01-2021/12280万元,在研,参加(合作单位主持)

    国家自然科学国际合作重点研究项目,61520106015,定量监测光动力血管损伤的多模光学成像技术研究,2016/01-2020/12250万元,在研,主持

    福建省自然科学杰出青年基金滚动资助项目,2014J07008,基于单线态氧发光成像的光动力血管损伤量效关系研究,2014/11-2017/1150万元,在研,主持

    国家自然科学基金面上项目,61275216,光动力学疗法中单线态氧的产生机制研究,2013/01-2016/1274万元,已结题,主持

    国家卫生计生委共建科学研究项目,WKJ-FJ-305-氨基酮戊酸光动力治疗皮肤癌的临床剂量学究研究,2013/11-2016/1115万元,已结题,主持

    国家自然科学基金重点项目,61036014,血管靶向光动力效应的量效关系及其监测技术研究,2011/01-2014/12240万元,已结题,参加(合作单位主持)

    福建省自然科学基金杰出青年项目,2011J06022PDT单线态氧的产量及其对细胞的杀伤机制研究,2011/01-2014/1225万元,已结题,主持

    国家自然科学基金面上项目,60978070,光动力学疗法的单线态氧剂量学研究, 2010/01-2012/1236万元,已结题,主持

教学情况:

  博士研究生:医学光子技术前沿

  硕士研究生:光电测量原理与技术

论文著作:

    [1]Li B, Xie S. Autofluorescence excitation-emission matrices for diagnosis of colonic cancer. World J Gastroenterol. 2005, 11(25): 3931-4.

    [2]Li B, Xie S, Zhang Z. Steady-state and time-resolved autofluorescence studies of human colonic cancer. Chin Opt Lett. 2006, 4(6):348-51.

    [3]Li B, Moriyama EH, Li F, Jarvi MT, Allen C, Wilson BC. Diblock copolymer micelles deliver hydrophobic protoporphyrin IX for photodynamic therapy. Photochem Photobiol. 2007, 83(6):1505-12.

    [4]Moriyama EH, Niedre MJ, Jarvi MT, Mocanu JD, Moriyama Y, Subarsky P, Li B, Lilge LD, Wilson BC. The influence of hypoxia on bioluminescence in luciferase-transfected gliosarcoma tumor cells in vitro. Photochem Photobiol Sci. 2008, 7(2):675-80.

    [5]Li B, lin L. Lin H, Xie S. Singlet oxygen quantum yields of porphyrin-based photosensitizers for photodynamic therapy, J Innov Opt Health Sci. 2008, 1(1):141-9.

    [6]Li B, Xie S, Huang ZWilson BC. Advances in Photodynamic Therapy dosimetry, Prog Biochem Biophy. 2009, 36(6): 676-83.

    [7]Xie S, Li H, Li B. Recent progress in medical photonics, Sci. China Ser. G-Phys. Mech. Astron. 2009, 52(6): 856-63).

    [8]Li B, Lin H, Chen D, Wang M, Xie S. Detection system for singlet oxygen luminescence in photodynamic therapy. Chin Opt Lett. 2010, 8(1): 86-8.

    [9]Li B, Chen Z, Liu L, Huang Z, Huang Z, Xie S. Differences in sensitivity to HMME-mediated photodynamic therapy between EBV+ C666-1 and EBV- CNE2 cells. Photodiagn Photodyn Ther. 2010, 7(3):204-9.

    [10]Huang T, Chen D, Su W, Lin H, Li B, Xie S. A new time-gated synchronization controller for the detection of singlet oxygen luminescence. Optoelectron Adv Mat. 2010, 4(8):1083-7.

    [11]Shen Y, Lin H, Huang Z, Chen D, Li B, Xie S. Indirect imaging of singlet oxygen generation from a single cell. Laser Phys Lett. 2011, 8(3): 232-8.

    [12]Lin H, Chen D, Wang M, Lin J, Li B, Xie S. Influence of pulse-height discrimination threshold for photon counting on the accuracy of singlet oxygen luminescence measurement. J Opt. 2011, 13(12): 125301.

    [13]Chen D, Zheng H, Huang Z, Lin H, Ke Z, Xie S, Li B. Light-emitting diode based illumination system for in vitro photodynamic therapy. Int J Photoenergy. 2012, 2012:920671.

    [14]Lei TC, Glazner GF, Duffy M, Scherrer L, Pendyala S, Li B, Wang X, Wang H, Huang Z. Optical properties of hematoporphyrin monomethyl ether (HMME), a PDT photosensitizer. Photodiagnosis Photodyn Ther. 2012, 9(3):232-42.

    [15]Wang Y, Zuo Z, Gu Y, Huang N, Chen R, Li B, Qiu H, Zeng J, Zhu J, Liang J. New optional photodynamic therapy laser wavelength for infantile port wine stains: 457 nm. J Biomed Opt. 2012, 17(6):068003.

    [16]Lin J, Yu Y, Li B, Huang H, Lin S, Li C, Su Y, Feng S, Chen G, Li Y, Huang Z, Zeng H, Chen R. Electrical pulse-mediated enhanced delivery of silver nanoparticles into living suspension cells for surface enhanced Raman spectroscopy. Laser Phys Lett. 2012, 9(3): 240-246.

    [17]Lin J, Chen R, Feng S, Pan J, Li B, Chen G, Lin S, Li C, Sun L, Huang Z, Zeng H. Surface-enhanced Raman scattering spectroscopy for potential noninvasive nasopharyngeal cancer detection. J Raman Spectrosc. 2012, 43(4): 497–502.

    [18]Li B, Lin H, Chen D Wilson BC, Gu Y. Singlet oxygen detection during photosensitization. J Innov Opt Health Sci. 2013, 6(1):1330002.

    [19]Liu L, Nie Y, Lin L, Li W, HuangZ, Li B, Xie S. Pattern recognition of multiple excitation autofluorescence spectra for colon tissue classification. Photodiagn Photodyn Ther. 2013, 10(2):111-9.

    [20]Lin L, Liu L, Huang H, Chen Y, Li B, Huang Z. Characterizing fluorescence lifetime of NAD(P)H in human leukemic myeloid cells and mononuclear cells. J Innov Opt Health Sci. 2013, 6(4):1350042.

    [21]Li D, Li P, Lin H, Jiang Z, Guo L, Li B .A novel chlorin-PEG-folate conjugate with higher water solubility, lower cytotoxicity, better tumor targeting and photodynamic activity. J Photochem Photobiol B. 2013, 127:28-37.

    [22]Lei T, Pendyala S, Scherrer L, Li B, Glazner G, Huang Z. Optical profiles of cathode ray tube and liquid crystal display monitors: implication in cutaneous phototoxicity in photodynamic therapy. Appl Opt. 2013, 52(12): 2711-7.

    [23]Lin H, Shen Y, Chen D, Lin L, Wilson BC, Li B, Xie S. Feasibility study on quantitative measurements of singlet oxygen generation using Singlet Oxygen Sensor Green, J Fluoresc. 2013, 23(1): 41-47.

    [24]Feng S, Lin D, Lin J, Li B, Huang Z, Chen G, Zhang W, Wang L, Pan J, Chen R, Zeng H. Blood plasma surface-enhanced Raman spectroscopy for non-invasive optical detection of cervical cancer. Analyst. 2013, 138(14): 3967-3974

    [25]Wang J, Feng S, Lin J, Zeng Y, Li L, Huang Z, Li B, Zeng H, Chen R. Serum albumin and globulin analysis for hepatocellular carcinoma detection avoiding false-negative results from alpha-fetoprotein test negative subjects. Appl Phys Lett. 2013, 103(20):204106

    [26]Lin J, Zeng Y, Lin J, Wang J, Li L, Huang Z, Li B, Zeng H, Chen R. Erythrocyte membrane analysis for type II diabetes detection using Raman spectroscopy in high-wavenumber region. Appl Phys Lett. 2014, 104(10): 104102

    [27]Chen L, Lin L, Li Y, Lin H, Qiu Z, Gu Y, Li B. Effect of oxygen concentration on singlet oxygen luminescence detection. J Lumines. 2014, 152:98-102.

    [28]Liu L,Yang C, Li W, Xie S, Li B. Analysis of colonic autofluorescence spectra using multivariate curve resolution alternating least squares. Chin Opt Lett. 2014, 12(5): 051705.

    [29]Qiu Z, Chen D, Wang Y, Yao G, Li B, Gu Y. Monitoring blood volume fraction and oxygen saturation in port-wine stains during vascular targeted photodynamic therapy with diffuse reflectance spectroscopy: Results of a preliminary case study. Photonics Laser Med. 2014, 3(3):273-280.

    [30]Lin J, Zeng Y, Lin J, Wang J, Li L, Huang Z, Li B, Zeng H, Chen R. Erythrocyte membrane analysis for type II diabetes detection using Raman spectroscopy in high-wavenumber region. Appl Phys Lett. 2014, 104(10): 104102

    [31]Wang J, Lin D, Lin J, Yu Y, Huang Z, Chen Y, Lin J, Feng S, Li B, Liu N, Chen R. Label-free detection of serum proteins using surface-enhanced raman spectroscopy for colorectal cancer screening. J Biomed Opt. 2014, 19(8):087003.

    [32]Lin L, Lin H, Chen D, Xie S, Gu Y, Wilson BC, Li B. Imaging of singlet oxygen luminescence in blood vessels. SPIE Newsroom, 2014, 10.1117/2.1201405.005511.

    [33]Lu P, Wang J, Lin J, Lin J, Liu N, Huang Z, Li B, Zeng H, Chen R. Gold nanoaggregates for probing single-living cell based on surface-enhanced Raman spectroscopy. J Biomed Opt. 2015, 20(5):051005.

    [34]Wilson BC, Patterson MS, Li B, Jarvi MT. Correlation of in vivo tumor response and singlet oxygen luminescence detection in mTHPC-mediated photodynamic therapy. J Innov Opt Health Sci. 2015, 8(1): 1540006.

    [35]Li B, R?der B. Singlet oxygen mediated photodynamic effects. Photonics Laser Med. 2015, 4(4):271-272.

    [36]Li B, R?der B. Congress Report on First Sino-German Symposium on Singlet molecular oxygen and photodynamic effects. Photonics Laser Med. 2015, 4(4):297-298.

    [37]Li B, Lin L, Gu Y, Wilson BC. Recent advances in optical imaging techniques for singlet oxygen luminescence. Photonics Laser Med. 2015, 4(4):308-310.

    [38]Chen D, Wang Y, Li B, Gu Y. Influence of pulse repetition rate on singlet oxygen production during photosensitization using a pulsed laser. Photonics Laser Med. 2015, 4(4):312-314.

    [39]Chen D, Ren J, Wang Y, Zhao H, Li B, Gu Y. Relationship between the blood perfusion values determined by laser speckle imaging and laser Doppler imaging in normal skin and port wine stains. Photodiagn Photodyn Ther. 2016, 14(1): 1-9.

    [40]Chen D, Wang Y, Li B, Lin H, Lin X, Gu Y. Effects of pulse width and repetition rate of pulsed laser on kinetics and production of singlet oxygen luminescence. J Innov Opt Health Sci. 2015, 2016, 9(6):1650019.

    [41]Qiu Z, Yao G, Chen D, Wang Y, Gu Y, Li B. Determination of optical and microvascular parameters of port wine stains using diffuse reflectance spectroscopy. Adv Exp Med Biol. 2016, 923: 359-65.

    [42]Chen M, Li H, Li B, Chen R, Zheng G, Song C. Fluorescence lifetimes of normal and carcinomatous human nasopharyngeal tissues. J Appl Spectrosc. 2016, 83(1): 61-5.

    [43]Liu X, Wei Z, Wu M, Zhang X, Zhang D,Li B, Liu J. A highly stable and biocompatible optical bioimaging nanoprobe based on carbon nanosphere, RSC Adv. 2016, 44(6):37472-7.

    [44]Chen D, Ren J, Wang Y, Li B, Gu Y. I ntraoperative monitoring of blood perfusion in port wine stains by laser Doppler imaging during vascular targeted photodynamic therapy: A preliminary study. Photodiagn Photodyn Ther. 2016, 14: 142-151.

    [45]Fan Z, Cui X, Wei W, Liu W, Li B, He H, Ye H, Zhu N, Wei X. eEF1A1 binds and enriches protoporphyrin IX in cancer cells in 5-aminolevulinic acid based photodynamic therapy. Sci Rep. 2016, 6: 25353.

    [46]Meng Z, Yu B,Han G, Liu M, Shan B, DongG, Miao Z, Jia N, Tan Z, Li B, Zhang W, Zhu H, Sheng C, Yao J. Chlorin p6-based water-soluble amino acid derivatives as potent photosensitizers for photodynamic therapy. J Med Chem. 2016, 59(10): 4999?5010.

    [47]Liu X, Lin X, Wu M, Lin R, Li B, Liu J. SPIONs@Cu2-xS nanoclusters for highly sensitive MRI and targeted photothermal therapy of hepatocellular carcinoma. J Mater Chem B, 2016, 23(4):4119-4129.

    [48]Li B, Lin L, Lin H, Wilson BC. Photosensitized singlet oxygen generation and detection: Recent advances and future perspectives in cancer photodynamic therapy. J Biophotonics. 2016, 9(11-12):1314-1325.

    [49]Lin J, Wang J, Xu C, Zeng Y, Chen Y, Li L, Huang Z, Li B, Chen R. Differentiation of digestive system cancers by using serum protein-based surface-enhanced Raman spectroscopy. J Raman Spectrosc. 2017, 48(1):16-21.

    [50]Pfitzner M, Schlothauer JC, Lin L, Li B, R?der B. Singlet oxygen luminescence imaging-a prospective tool in bioscience? in Imaging In Photodynamic Therapy, Edited by Hamblin MR and Huang Y. 2017, CRC Press, 67-87.

引导研究生:

  在读博士研究生:何华斌,许雪林

  在读硕士研究生:廖香莲,檀邹,张锦德,魏际远,梁富强,林昕,戴瑶梅,杨景


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